Antimicrobial resistance (AMR) – the ability of microorganisms to resist antibiotics, antifungals, and antivirals – is one of the greatest health threats of the 21st century. It also presents a major challenge to agricultural industries, with significant impacts for biosecurity, productivity, food safety and quality, and market access. Through focused collaboration between researchers and industry, CRC SAAFE will lead the AMR response for the Australian water, waste, agribusiness, and food sectors, anticipating and addressing future challenges and capitalising on emerging opportunities.